Comparative clinical effectiveness of oral probiotics and oral fexofenadine in patients with allergic rhinitis: a prospective study
DOI:
https://doi.org/10.51168/06trtw67Cuvinte cheie:
Allergic Rhinitis, Probiotics, FexofenadineRezumat
Background
Allergic rhinitis (AR) is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens and is one of the most common chronic conditions globally. Treated by multi modal therapy it involves methods to reducing allergen oral or topical anti-histamines, intranasal or systemic corticosteroids and oral probiotics.
Objective
1. Comparing the efficacy of oral probiotics and fexofenadine 120 mg in alleviating the symptoms of allergic rhinitis.
2. To compare the effect of the two drugs on nasal congestion, rhinorrhea, sneezing, and nasal itching.
3. Evaluating changes in Total Nasal Symptom Score after taking oral probiotics and fexofenadine.
4. Determining the more effective medication for each symptom in patients suffering from allergic rhinitis.
Method
A total of 120 patients visiting ENT OPD, Navodaya medical college, Raichur undergoing treatment for allergic rhinitis were included in the present study for period of 18 months from June 2023 to December 2024. 60 patients were given oral fexofenadine and 60 patients were given oral probiotics. Selection of the patients was done randomly.
Results
The participants were assessed through the Total Nasal Symptom Score (TNSS), where they were evaluated based on nasal congestion, runny nose, sneezing, itching, and other symptoms that impacted their sleep, lifestyle, and productivity. Probiotics yielded a better effect in treating nasal congestion, while fexofenadine 120 mg was more effective in treating the symptoms of runny nose, sneezing, and itching. Out of all the evaluated symptoms, only one of them (runny nose) was found to be statistically significantly reduced with fexofenadine.
Conclusion
Oral probiotics may help in relieving nasal congestion, whereas fexofenadine 120 mg helps in treating rhinorrhea, sneezing, and itching, particularly rhinorrhea.
Recommendation
Larger prospective studies are needed to ascertain efficacy, treatment length, and use as adjunctive therapy in individuals with allergic rhinitis and nasal obstruction.
Referințe
1. Bousquet J, Anto JM, Bachert C, Baiardini I, Bosnic-Anticevich S, Walter Canonica G, Melén E, Palomares O, Scadding GK, Togias A, Toppila-Salmi S. Allergic rhinitis. Nature reviews Disease primers. 2020 Dec 3;6(1):95. https://doi.org/10.1038/s41572-020-00227-0
2. Testera-Montes A, Jurado R, Salas M, Eguiluz-Gracia I, Mayorga C. Diagnostic tools in allergic rhinitis. Frontiers in allergy. 2021 Sep 23;2:721851. https://doi.org/10.3389/falgy.2021.721851
3. Mortada MM, Kurowski M. Challenges in local allergic rhinitis diagnosis, management, and research: current concepts and future perspectives. Medicina. 2023 May 11;59(5):929. https://doi.org/10.3390/medicina59050929
4. Reid G. Probiotic Lactobacilli for urogenital health in women. Journal of clinical gastroenterology. 2008 Sep 1;42:S234-6. https://doi.org/10.1097/MCG.0b013e31817f1298
5. Howarth PH, Stern MA, Roi L, Reynolds R, Bousquet J. Double-blind, placebo- controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. Journal of allergy and clinical immunology. 1999 Nov 1;104(5):927-33. https://doi.org/10.1016/S0091-6749(99)70070-9
6. Gentile DA, Friday GA, Skoner DP. Management of allergic rhinitis: antihistamines and decongestants. Immunology and Allergy Clinics. 2000 May 1;20(2):355-68. https://doi.org/10.1016/S0889-8561(05)70152-1
7. Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G. A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatric research. 2007 Aug;62(2):215-20. https://doi.org/10.1203/PDR.0b013e3180a76d94
8. Xiao Y, Zhai Q, Zhang H, Chen W, Hill C. Gut colonization mechanisms of Lactobacillus and Bifidobacterium: an argument for personalized designs. Annual Review of Food Science and Technology. 2021 Mar 25;12(1):213-33. https://doi.org/10.1146/annurev-food-061120-014739
9. Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G. A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatric research. 2007 Aug;62(2):215-20. https://doi.org/10.1203/PDR.0b013e3180a76d94
10. Miyabe S, Koizuka I, Ochi K, Tanaka K, Kuroda H, Takatsu M, Kinoshita H, Sugiyama Y. Effect of fexofenadine hydrochloride on cedar pollinosis. Auris Nasus Larynx. 2003 Feb 15;30:61-8. https://doi.org/10.1016/S0385-8146(02)00138-4
11. Meltzer EO, Scheinmann P, Rosado Pinto JE, Bachert C, Hedlin G, Wahn U, Finn Jr AF, Ruuth E. Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis-a pooled analysis of three studies. Pediatric allergy and immunology. 2004 Jun;15(3):253-60.
https://doi.org/10.1111/j.1399-3038.2004.00167.x
12. Juniper EF, Cartier A, Trebilcock AL, Frith PA, Dolovich J, Hargreave FE. Effects of oxatomide compared with chlorpheniramine in allergic rhinoconjunctivitis. Clinical & Experimental Allergy. 1981 Jan;11(1):61-6... https://doi.org/10.1111/j.1365-2222.1981.tb01567.x
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Copyright (c) 2026 Dr. Shriya Basti, Dr. Shweta Sawant, Dr. Darshan M
TAceastă lucrare este licențiată în temeiul Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
