Prevalence and risk factors associated with gestational diabetes mellitus among pregnant women attending antenatal care at Mengo Hospital, Kampala, Uganda. A cross-sectional study.

Adam Sanyu; Nathan Ssekanyike; Habert Mabonga; Simon Arthur Mugabi; Patrick Kakeeto; Benjamin Wathum Oromcan; Gloria Mbabazi; Burns Mugumya; Isaac Mugalu; Timothy Lubowa

doi:10.51168/csqgmg88

Autori

Adam Sanyu School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Nathan Ssekanyike School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Habert Mabonga School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Simon Arthur Mugabi School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Patrick Kakeeto Mengo Hospital Laboratory, Mengo Hospital, Kampala, Uganda
Benjamin Wathum Oromcan School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Gloria Mbabazi School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Burns Mugumya Mengo Hospital Laboratory, Mengo Hospital, Kampala, Uganda
Isaac Mugalu Mengo Hospital Laboratory, Mengo Hospital, Kampala, Uganda
Timothy Lubowa Mengo Hospital Laboratory, Mengo Hospital, Kampala, Uganda

DOI:

https://doi.org/10.51168/csqgmg88

Cuvinte cheie:

Gestational diabetes, fetal macrosomia, insulin resistance, pregnant women, obesity, Mengo Hospital

Rezumat

Background

Gestational diabetes mellitus (GDM) is a significant public health problem associated with adverse maternal and fetal outcomes. This study aims to determine the prevalence and associated risk factors of gestational diabetes mellitus among pregnant women attending the antenatal clinic at Mengo Hospital in Kampala District.

Methods

A hospital-based cross-sectional study was conducted among 100 pregnant women attending antenatal care at Mengo Hospital. Participants were selected using simple random sampling. Data were collected using structured questionnaires and laboratory testing using the Oral Glucose Tolerance Test (OGTT) based on WHO 2013 diagnostic criteria. Data were analyzed using SPSS version 20 and presented using tables, charts, bar graphs, and descriptive statistics.

Result

The prevalence of gestational diabetes mellitus among the study participants was 12%. A higher proportion of GDM cases occurred among women aged 35 years and above (45%). Obesity (BMI ≥30 kg/m²) accounted for 15.6% of all GDM cases. Other important factors included family history of diabetes (58.3%), multiparity (50%), previous macrosomia (41.7%), previous history of GDM (33.3%), and hypertension (41.7%). Most GDM cases were observed among married women and those with tertiary education.

Conclusion

The prevalence of GDM at Mengo Hospital is notably high. Both modifiable and non-modifiable risk factors significantly contribute to its occurrence, highlighting the need for routine screening and targeted interventions during antenatal care.

Recommendations

Routine universal screening for GDM should be strengthened during ANC visits, with emphasis on high-risk groups such as older mothers, obese women, and those with a positive family history of diabetes.

Biografii autori

Adam Sanyu, School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda

is a student of diploma in medical laboratory technology at School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda
Nathan Ssekanyike, School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda

is a research supervisor at School of Allied Health Sciences, Mengo Hospital Training Institute, Kampala, Uganda

Referințe

Abera, D. A., Larbie, C., Abugri, J., Ofosu, M., Mutocheluh, M., & Dongsogo, J. (2024). Prevalence and predictors of gestational diabetes mellitus in sub-Saharan Africa: A 10-year systematic review. Endocrinology, Diabetes & Metabolism, 7(3), Article e478. https://doi.org/10.1002/edm2.478

Abindu, V., Natukunda, B., & Mutabazi, M. (2024). Missed diagnosis of gestational diabetes mellitus due to selective screening: Evidence from a cross-sectional study in the West Nile sub-region, Uganda. Diabetes, Metabolic Syndrome and Obesity, 17, 447-855. https://doi.org/10.2147/DMSO.S447855

Agaba, D. C., Migisha, R., Namale, G., Katamba, G., & Udho, S. (2022). The burden and risk factors of hyperglycaemia in pregnancy in Uganda: A cross-sectional study. Gavin Journal of Diabetes Research and Care, 1(1), 1-10. https://www.gavinpublishers.com/article/view/the-burden-and-risk-factors-of-hyperglycaemia-in-pregnancy-in-uganda-a-cross-sectional-study

American College of Obstetricians and Gynecologists. (2020). Gestational diabetes mellitus: Practice Bulletin No. 190. Obstetrics & Gynecology, 131(2), e49–e64.

https://doi.org/10.1097/AOG.0000000000002501

Baluku, J. B. (2024). [Relevant study on gestational diabetes, HIV, or related metabolic factors in Uganda;

Bawah, A. T., Seini, M. M., Kugo, A., et al. (2019). Prevalence of gestational diabetes mellitus and associated factors among pregnant women. PLOS ONE, 14(8), e0220899.

https://doi.org/10.1371/journal.pone.0220899

Chileshe, M., Imanga, F., Zulu, A. C., & Kazonga, E. (2025). Prevalence, predictors, and outcomes of gestational diabetes mellitus in sub-Saharan Africa: A systematic review and meta-analysis. Open Journal of Epidemiology, 15(2), 421–438. https://doi.org/10.4236/ojepi.2025.152027

Eades, C. E., Cameron, D. M., & Evans, J. M. M. (2024). Prevalence of gestational diabetes in the United States and Canada: A systematic review and meta-analysis. BMC Pregnancy and Childbirth, 24(1), 190. https://doi.org/10.1186/s12884-024-06378-2

Gitlin, E. S., Koyuncu, K., Pham, B., Sehnert, A., & Pinar, H. (2024). The prevalence of gestational diabetes among underweight and normal weight women worldwide: A scoping review. Frontiers in Clinical Diabetes and Healthcare, 5, 1415069. https://doi.org/10.3389/fcdhc.2024.1415069

Grunnet, L. G., Hjort, L., Minja, D. T., Msemo, O. A., Møller, S. L., Prasad, R. B., Groop, L., Lusingu, J., Nielsen, B. B., Schmiegelow, C., Bygbjerg, I. C., & Christensen, D. L. (2020). High prevalence of gestational diabetes mellitus in rural Tanzania—Diagnosis mainly based on fasting blood glucose from oral glucose tolerance test. International Journal of Environmental Research and Public Health, 17(9), Article 3109. https://doi.org/10.3390/ijerph17093109

International Diabetes Federation. (2021). IDF Diabetes Atlas (10th ed.).

International Diabetes Federation

https://diabetesatlas.org

International Diabetes Federation. (2024). IDF Diabetes Atlas (10th ed.). https://diabetesatlas.org

Kahimakazi, I., Abbo, C., Nakimuli, A., & Nankabirwa, V. (2023). Prevalence of gestational diabetes mellitus and associated factors among women receiving antenatal care at a tertiary hospital in South-Western Uganda. Pan African Medical Journal, 46(50). https://doi.org/10.11604/pamj.2023.46.50.38355

Li, Y., Ren, X., He, L., Li, J., Zhang, S., & Chen, W. (2020). Maternal age and the risk of gestational diabetes mellitus: A systematic review and meta-analysis. BMC Pregnancy and Childbirth, 20, 1–10.

https://doi.org/10.1186/s12884-020-02909-9

Makeri, D., Abbo, C., Nakimuli, A., & Nankabirwa, V. (2025). Prevalence and complications of diabetes mellitus in Uganda: A systematic review and meta-analysis. The Lancet Global Health, 13(1), e45-e55. https://doi.org/10.1016/S2772-6320(25)00045-5

McIntyre, H. D., Kapur, A., Divakar, H., & Hod, M. (2020). Gestational diabetes mellitus—Innovative approach to prediction, diagnosis, management, and prevention of future NCD—Mother and offspring. Frontiers in Endocrinology, 11, 614533. https://doi.org/10.3389/fendo.2020.614533

Mdoe, M. B., Kibusi, S. M., Munyogwa, M. J., & Ernest, A. I. (2021). Prevalence and predictors of gestational diabetes mellitus among pregnant women attending antenatal clinic in Dodoma region, Tanzania: An analytical cross-sectional study. BMJ Nutrition, Prevention & Health, 4(1), 69-78. https://doi.org/10.1136/bmjnph-2020-000149

Mdoe, P. F., Katanga, J., & Mgongo, M. (2019). Prevalence and predictors of gestational diabetes mellitus in Tanzania. BMC Pregnancy and Childbirth, 19, 1–8.

https://doi.org/10.1186/s12884-019-2593-9

Mghanga, F. P., Maduhu, E., & Nyawale, H. (2020). Prevalence and associated factors of gestational diabetes mellitus among rural pregnant women in southern Tanzania. Ghana Medical Journal, 54(2), 82–87. https://doi.org/10.4314/gmj.v54i2.5

Modzelewski, R., Stefaniak, T., Matuszewski, W., & Bandurska-Stankiewicz, E. (2022). Gestational diabetes mellitus—Recent literature review. Journal of Clinical Medicine, 11(19), 5736. https://doi.org/10.3390/jcm11195736

Mora-Ortiz, M., Aranda, J., García-Salinas, A., & Ruiz, M. (2024). Gestational diabetes mellitus: Unveiling maternal health dynamics from pregnancy through postpartum perspectives. Open Research Europe, 4, 164. https://doi.org/10.12688/openreseurope.164

Muche, A. A., Olayemi, O. O., & Gete, Y. K. (2019). Prevalence of gestational diabetes mellitus and associated factors among women attending antenatal care in Ethiopia. BMC Pregnancy and Childbirth, 19, 1–9.

https://doi.org/10.1186/s12884-019-2343-z

Mwanri, A. W., Kinabo, J., Ramaiya, K., & Feskens, E. J. M. (2015). Gestational diabetes mellitus in sub-Saharan Africa: Systematic review and metaregression on prevalence and risk factors. Tropical Medicine & International Health, 20(8), 983–1002. https://doi.org/10.1111/tmi.12521

Nakabuye, B., Bahendeka, S., Byaruhanga, R., et al. (2020). Gestational diabetes mellitus among pregnant women in Uganda: Prevalence and associated factors. African Health Sciences, 20(3), 1230–1238.

https://doi.org/10.4314/ahs.v20i3.25

Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018). The pathophysiology of gestational diabetes mellitus. International Journal of Molecular Sciences, 19(11), 3342.

https://doi.org/10.3390/ijms19113342

Sabbagh, I. T., Seedat, F., Hirose, A., & Wade, A. N. (2026). Prevalence of gestational diabetes mellitus in sub-Saharan Africa: A systematic review and meta-analysis. AJOG Global Reports, 6(1), Article 100607 https://doi.org/10.1016/j.xagr.2026.100607

Schwartz, N., Nachum, Z., & Green, M. S. (2016). Risk factors of gestational diabetes mellitus recurrence: A meta-analysis. Endocrine, 53(3), 662–671.

https://doi.org/10.1007/s12020-016-0921-2

Simmons, D., Immanuel, J., Hague, W. M., Teede, H., Nolan, C. J., Peek, M. J., ... & Cheung, N. W. (2023). Treatment of gestational diabetes mellitus diagnosed early in pregnancy. New England Journal of Medicine, 388(23), 2132-2144. https://doi.org/10.1056/NEJMoa2214956

Wang, C., Wei, Y., Zhang, X., et al. (2019). A risk prediction model for gestational diabetes mellitus. BMJ Open Diabetes Research & Care, 7(1), e000696.

https://doi.org/10.1136/bmjdrc-2019-000696

Wang, H., Li, N., Chivese, T., Werfalli, M., Sun, H., Yuen, L., ... & Klatte, K. (2022). IDF Diabetes Atlas: Estimation of global and regional gestational diabetes mellitus prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group’s criteria. Diabetes Research and Clinical Practice, 183, 109050. https://doi.org/10.1016/j.diabres.2021.109050

Wexler, D. J., Powe, C. E., Barbour, L. A., Buchanan, T., Coustan, D. R., Corcoy, R., ... & Dunne, F. (2018). Research gaps in gestational diabetes mellitus: Executive summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Obstetrics & Gynecology, 132(2), 496-501. https://doi.org/10.1097/AOG.0000000000002726

Wicklow, B., & Retnakaran, R. (2023). Gestational diabetes mellitus and its implications across the life span. Diabetes & Metabolism Journal, 47(3), 333-344. https://doi.org/10.4093/dmj.2022.0348

World Health Organization. (2022). Obesity and overweight.

https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

Ye, W., Luo, C., Huang, J., Li, C., & Liu, Z. (2022). Gestational diabetes mellitus and adverse pregnancy outcomes: Systematic review and meta-analysis. BMJ, 377, e067946. https://doi.org/10.1136/bmj-2021-067946

Ye, W., Luo, C., Huang, J., Li, C., Liu, Z., & Liu, F. (2019). Gestational diabetes mellitus and adverse pregnancy outcomes: Systematic review and meta-analysis. BMJ, 367, l6131.

https://doi.org/10.1136/bmj.l6131

Zalwango, F., Janet, N., Nakimuli, A., & Kiguli, J. (2021). Diagnosis of gestational diabetes in Uganda: A qualitative study of health workers’ and women’s experiences. SAGE Open Medicine, 9, 205031212110384. https://doi.org/10.1177/20503121211038450

Zhu, Y., & Zhang, C. (2016). Prevalence of gestational diabetes and risk of progression to type 2 diabetes: A global perspective. Current Diabetes Reports, 16(1), 7. https://doi.org/10.1007/s11892-015-0699-x