Medicinal uses and ethnopharmacological properties of Terminalia brachystemma Welw. ex Hiern: A narrative review.

Alfred Maroyi

doi:10.51168/cw8x4g12

Autori

Alfred Maroyi Department of Biotechnology and Biological Sciences, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

DOI:

https://doi.org/10.51168/cw8x4g12

Cuvinte cheie:

Bush willow family, Combretaceae, Kalahari cluster-leaf, materia medica, Terminalia brachystemma

Rezumat

Terminalia brachystemma Welw. ex Hiern, which belongs to the Combretaceae family, is a slender, Semi-deciduous shrub or small tree. It has been recorded in bushveld and swamp forests of east and southern Africa in Angola, Botswana, Democratic Republic of Congo, Malawi, Mozambique, Namibia, South Africa, Tanzania, Zambia and Zimbabwe. The study is aimed at summarizing medicinal uses and chemical and biological properties of T. brachystemma based on information in the literature. The ethnobotany and ethnopharmacological review of T. brachystemma was done through a literature review of several online databases such as ScienceDirect®, PubMed®, Web of Science, SpringerLink®, Google Scholar, Scopus® and SciELO, as well as pre-electronic literature sources such as book chapters, books and other scientific publications obtained from the university library. The following keywords were applied during the literature search: “biological activities”, “ethnobotany”, “medicinal uses”, “pharmacological properties”, “phytochemistry” and “traditional uses of T. brachystemma”. The research findings highlight the use of the bark, leaves and roots of T. brachystemma as an antidote for nephralgia, and traditional medicine for allergies, toothache, bilious vomiting, sexually transmitted infections, respiratory infections, bilharzia and gastrointestinal disorders. Chemical compounds identified from T. brachystemma include betulinic acid, catechin, chebulanin, isoorientin, isovitexin, orientin, punicalagin, and ursolic acid. The phytochemical compounds isolated from T. brachystemma and its crude extracts exhibited anthelmintic, antibacterial, antifungal, and antioxidant activities. Future research on T. brachystemma should focus on detailed phytochemical, pharmacological, and toxicological evaluations, as well as in vivo and clinical studies.

Biografie autor

Alfred Maroyi, Department of Biotechnology and Biological Sciences, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

is a Professor of Botany in the Department of Biotechnology and Biological Sciences, University of Fort Hare

Referințe

1. Anokwuru, C.P., Sandasi, M., Chen, W., Van Vuuren, S., Elisha, I.L., Combrinck, S., and Viljoen, A.M. (2021). Investigating antimicrobial compounds in South African Combretaceae species using a biochemometric approach. Journal of Ethnopharmacology, 269, 113681. https://doi.org/10.1016/j.jep.2020.113681

2. Anokwuru, C.P., Chen, W., Van Vuuren, S., Combrinck, S., and Viljoen, A.M. (2022). Bioautography-guided HPTLC–MS as a rapid hyphenated technique for the identification of antimicrobial compounds from selected South African Combretaceae species. Phytochemical Analysis, 33(8), 1177- 1189. https://doi.org/10.1002/pca.3167

3. Aparicio, H., Hedberg, I., Bandeira, S., and Ghorbani, A. (2021). Ethnobotanical study of medicinal and edible plants used in Nhamacoa area, Manica province, Mozambique. South African Journal of Botany, 139, 318-328. https://doi.org/10.1016/j.sajb.2021.02.029

4. Arnold, T.H., Prentice, C.A., Hawker, L.C., Snyman, E.E., Tomalin, M., Crouch, N.R., and Pottas-Bircher, C. (2002). Medicinal and magical plants of southern Africa: An annotated checklist. National Botanical Institute, Strelitzia 13, Pretoria.

5. Barroso, A.A., Martins, A.A., Morais, A., Katenda, P.C.F., Jamba, M.F., Gonçalves, M.F.A., Sebastião, M.A., Chimbuco, B.N., Hernández, Y.S., Mota, D.S., Ribalta, V.R., Gomes, A., Barreto, E.H., and Ekundi-Valentim, E. (2026). An ethnopharmacological assessment of medicinal plants in Malanje Municipality, Angola. Frontiers in Pharmacology, 16, 1702353. https://doi.org/10.3389/fphar.2025.1702353

6. Chakrabarty, T., Krishna, G., and Rasingam, L. (2019). Taxonomic notes on Indian Terminalia (Combretaceae). Plant Science Today, 6(3), 281–286. https://doi.org/10.14719/pst.2019.6.3.539.

7. Chinemana, F., Drummond, R.B., Mavi, S., and De Zoysa, I. (1985). Indigenous plant remedies in Zimbabwe. Journal of Ethnopharmacology, 14, 159-172. https://doi.org/10.1016/0378-8741(85)90084-4

8. Christenhusz, M.J.M., and Byng, J.W. (2016). The number of known plant species in the world and its annual increase. Phytotaxa, 261(3), 201–217. https://doi.org/10.11646/phytotaxa.261.3.1.

9. Cock, I.E. (2015). The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae). Inflammopharmacology, 23(5), 203-229. https://doi.org/10.1007/s10787-015-0246-z.

10. Das, G., Kim, D.-Y., Fan, C., Gutiérrez-Grijalva, E.P., Heredia, J.B., Nissapatorn, V, Mitsuwan, W., Pereira, M.L., Nawaz, M., Siyadatpanah, A., Norouzi, R., Sawicka, B., Shin, H.-S., and Patra, J.K. (2020). Plants of the genus Terminalia: An insight into its biological potentials, pre-clinical and clinical studies. Frontiers in Pharmacology, 11, 561248. https://doi.org/10.3389/fphar.2020.561248

11. Dzoyem, J.P., and Kuete, V. (2013). Review of the antifungal potential of African medicinal plants. In: Razzaghi-Abyaneh, M., and Rai, M. (editors). Antifungal metabolites from plants. Springer, London, pp. 79–153. https://doi.org/10.1007/978-3-642-38076-1-4

12. Eloff, J.N. (1999). The antibacterial activity of 27 Southern African members of the Combretaceae. South African Journal of Science, 95, 148–152

13. Fahmy, N., Al-Sayed, E., and Singab, A. (2015). Genus Terminalia: A phytochemical and biological review. Medicinal and Aromatic Plants, 4, 1000218. https://doi.org/10.4172/2167-0412.1000218.

14. Gelfand, M., Mavi, S., Drummond, R.B., and Ndemera, B. (1985). The traditional medical practitioners in Zimbabwe: Their principles of practice and pharmacopoeia. Mombo Press, Gweru.

15. Gere, J., Yessoufou, K., Daru, B.H., Maurin, O., and Van Der Bank, M. (2015). The African continent is a likely origin of the family Combretaceae (Myrtales). A biogeographical view. Annual Research and Review in Biology, 8, 1–20. https://doi.org/10.9734/ARRB/2015/17476

16. Germishuizen, G., and Meyer, N.L. (2003). Plants of southern Africa: An annotated checklist. Strelitzia 14, National Botanical Institute, Pretoria.

17. Harvey, T.E.C., and Armitage, F.B. (1961). Some herbal remedies and observations on the Nyanga of Matabeleland. Central African Journal of Medicine, 7, 193-207.

18. Jordaan, M., Van Wyk, A.E., and Maurin, O. (2011). A conspectus of Combretum (Combretaceae) in southern Africa, with taxonomic and nomenclatural notes on species and sections. Bothalia, 41(1), 135–160. https://doi.org/10.4102/abc.v41i1.36

19. Lautenschläger, T., Monizi, M., Pedro, M., Mandombe, J.L., Bránquima, M.F., Heinze, C., and Neinhuis, C. (2018). First large-scale ethnobotanical survey in the province of Uíge, northern Angola. Journal of Ethnobiology and Ethnomedicine, 14, 51. https://doi.org/10.1186/s13002-018-0238-3

20. Leistner, O.A. (2000). Seed plants of southern Africa: Families and genera. Strelitzia 10, National Botanical Institute, Pretoria.

21. Kumar, P., and Kataria, V. (2026). Resolving species delimitation in Terminalia L. (Combretaceae) using a multilocus DNA barcoding approach. Plant Gene, 45, 100574. https://doi.org/10.1016/j.plgene.2026.100574

22. Liu, M., Seidel, V., Katerere, D.R., and Gray, I.A. (2007). Colorimetric broth microdilution method for the antifungal screening of plant extracts against yeasts. Methods, 42, 325–329. https://doi.org/10.1016/j.ymeth.2007.02.013.

23. Liu, M., Katerere, D.R., Gray, A.I., and Seidel, V. (2009). Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. Fitoterapia, 80, 369–373. https://doi.org/10.1016/j.fitote.2009.05.006.

24. Maroyi, A. (2019). Use of ethnomedicinal herbs to treat and manage schistosomiasis in Zimbabwe: Past trends and future directions. In: Martinez, J.L., Munoz-Acevedo, A., and Rai, M. (editors). Ethnobotany: Application of medicinal plants. CPC Press, London, pp. 36-47.

25. Maroyi, A. (2025a). An overview of medicinal uses, phytochemical and pharmacological properties of Terminalia brownii Fresen. Plant Science Today, 12(4), 1-20. https://doi.org/10.14719/pst.6556

26. Maroyi, A. (2025b). Medicinal uses and pharmacological properties of Terminalia kaiserana F.Hoffm. (Combretaceae family). Student’s Journal of Health Research Africa, 6, 9. https://doi.org/10.51168/sjhrafrica.v6i9.2003

27. Maroyi, A. (2025c). A review of the ethnomedicinal uses, phytochemistry, and pharmacological activities of Terminalia mollis M.A.Lawson (Combretaceae). Pakistan Journal of Biological Sciences, 28(12), 715-726. https://doi.org/10.3923/pjbs.2025.715.726

28. Maroyi, A. (2025d). Ecology, botany, and medicinal properties of Terminalia myrtifolia (M.A.Lawson) Gere & Boatwr. (Combretaceae). Pakistan Journal of Biological Sciences, 28, 677-684. https://doi.org/10.3923/pjbs.2025.677.684.

29. Maroyi, A. (2025e). Terminalia phanerophlebia Engl. & Diels: Evaluation of its medicinal uses, phytochemical and pharmacological properties. Medicinal Plants International Journal of Phytomedicines and Related Industries, 16(4), 635-643. https://doi.org/10.5958/0975-6892.2025.00029.5

30. Maroyi, A. (2025f). Terminalia prunioides M.A. Lawson (Combretaceae family): A comprehensive review of its medicinal uses, phytochemical and pharmacological properties. Medicinal Plants International Journal of Phytomedicines and Related Industries, 16(4), 454-464. https://doi.org/10.5958/0975-6892.2025.00046.2

31. Maroyi, A. (2025g). Medicinal uses, phytochemical and pharmacological properties of Terminalia sambesiaca Engl. & Diels (Combretaceae). Asian Journal of Pharmaceutical and Clinical Research, 18(10), 15-22. https://doi.org/10.22159/ajpcr.2025v18i10.55088

32. Maroyi, A. (2025h). Terminalia spinosa Engl.: A review of its medicinal applications, phytochemical constituents, and pharmacological activities. Pakistan Journal of Biological Sciences, 28, 727-734. https://doi.org/10.3923/pjbs.2025.727.734.

33. Maroyi, A. (2025i). Ethnobotany and ethnopharmacological properties of Terminalia stenostachya Engl. & Diels: A narrative review. Journal of Natural and Applied Sciences Pakistan, 7(2), 2250-2263

34. Maroyi, A. (2025j). Taxonomy, traditional uses and pharmacological properties of Ormocarpum trichocarpum (Taub.) Engl. (Fabaceae Family): A narrative review. Pakistan Journal of Biological Sciences, 27, 626-634. https://doi.org/10.3923/pjbs.2024.626.634

35. Masoko, P., and Eloff, J.N. (2007). Screening of twenty-four South African Combretum and six Terminalia species (Combretaceae) for antioxidant activities. African Journal of Traditional Complementary and Alternative Medicine, 4(2), 231-239. https://doi.org/10.4314/ajtcam.v4i2.31213

36. Masoko, P., and Eloff, J.N. (2005). The diversity of antifungal compounds of six South African Terminalia species (Combretaceae) determined by bioautography. African Journal of Biotechnology, 4(12), 1425-1431.

37. Masoko, P., Picard, J., and Eloff, J.N. (2005). Antifungal activities of six South African Terminalia species (Combretaceae). Journal of Ethnopharmacology, 99, 301–308. https://doi.org/10.1016/j.jep.2005.01.061.

38. Maurin, O., Anest, A., Forest, F., Turner, I., Barrett, R.L., Cowan, R.C., Wang, L., Tomlinson, K.W., and Charles-Dominique, T. (2023). Drift in the tropics: Phylogenetics and biogeographical patterns in Combretaceae. Global Ecology and Biogeography, 32, 1790–1802. https://doi.org/10.1111/geb.13737

39. Mølgaard, P., Nielsen, S.B., Rasmussen, D.E., Drummond, R.B., Makaza, N., and Andreassen, J. (2001). Anthelmintic screening of Zimbabwean plants traditionally used against schistosomiasis. Journal of Ethnopharmacology, 74, 257-264. https://doi.org/10.1016/s0378-8741(00)00377-9.

40. Mwangi, V.I., Mumo, R.M., Nyachieo, A., and Onkoba, N. (2017). Herbal medicine in the treatment of poverty-associated parasitic diseases: A case of sub-Saharan Africa. Journal of Herbal Medicine, 10, 107. https://doi.org/10.1016/j.hermed.2017.03.002.

41. Ndamba, J., Nyazema, N., Makaza, N., Anderson, C., and Kaondera, K.C. (1994). Traditional herbal remedies used for the treatment of urinary schistosomiasis in Zimbabwe. Journal of Ethnopharmacology, 42, 125-132. https://doi.org/10.1016/0378-8741(94)90106-6

42. Neo-Mahupeleng, G., Rampart, M., Makgobota, K., Obusitswe, K., Makoi, T., Kgosiesele, E., Mmolotsi, R., Mojeremane, W., and Teketay, D. (2025). Herbivore browse utilisation and selection in the Kazuma Forest Reserve, northern Botswana. Frontiers in Forests and Global Change, 8, 1500962. https://doi.org/10.3389/ffgc.2025.1500962.

43. Neuwinger, H.D. (2000). African traditional medicine. MedPharm Scientific Publishers, Stuttgart.

44. Novotna, B., Polesny, Z., Pinto-Basto, M.F., Van Damme, P., Pudil, P., Mazancovae, J., and Duarte, M.C. (2020). Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola. Journal of Ethnopharmacology, 260, 112662. https://doi.org/10.1016/j.jep.2020.112662.

45. Nyagumbo, E., Nyirenda, T., Mawere, C., Mutasa, I., Kademeteme, E., Mutaramutswa, A.M., Kapanga, D., Ngorima, G., Nhari, L., Maunganidze, F., Bhebhe, M., Pote, W., and Mabaya, L. (2024a). Medicinal plants used for the treatment and management of bilharziasis and other parasitic infections affecting humans in Zimbabwe: A systematic review. In: de Oliveira, M.S., Andrade, E.H.A., Kumar, R., and Mali, S.N. (editors). Medicinal plants: chemical, biochemical, and pharmacological approaches. Intechopen Limited, London, pp. 233-282. https://doi.org/10.5772/intechopen.113291.

46. Nyagumbo, E., Nyirenda, T., Mawere, C., Mutaramutswa, A., Ngorima, G., Kapanga, D.T., Nhari, L., Matsheza, M., Midzi, C., Pote, W., Maunganidze, F., Mabaya, L., and Bhebhe, M. (2024b). An overview of medicinal plant species used in treating and managing diarrhea by Zimbabwean traditional healers: A toxicological assessment. In: Waisundara, V.Y. (editor). Medicinal plants: Harnessing the healing power of plants. Intechopen Limited, London, pp. 67-101. https://doi.org/10.5772/intechopen.1006302.

47. Ojewole, J.A.O. (2004). Indigenous plants and schistosomiasis control in South Africa: Molluscicidal activity of some Zulu medicinal plants. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 3, 10.

48. Palgrave, C.K. (2002). Coates Palgrave trees of southern Africa. C Struik Publishers, Cape Town.

49. Palmer, E., and Pitman, N. (1972). Trees of southern Africa: Covering all known indigenous species in the Republic of South Africa, South-West Africa, Botswana, Lesotho, and Swaziland. Balkema, Cape Town.

50. Quattrocchi, U. (2012). CRC world dictionary of medicinal and poisonous plants: common names, scientific names, eponyms, synonyms, and etymology. CRC Press, Boca Raton.

51. Raj, S.P., Solomon, P.R., and Thangaraj, B. (2022). Combretaceae. In: Raj, S.P., Solomon, P.R., and Thangaraj, B. (editors). Biodiesel from flowering plants. Springer, Singapore, pp. 159–164. https://doi.org/10.1007/978-981-16-4775-8_12

52. Rayane, T., Ribeiro, M., Maria, I., Loiola, B., and Margareth, F.D.E.S. (2022). Look at the trees: synopsis of Terminalia ss in the Brazilian Amazon with conservation and distribution implications. Anais da Academia Brasileira de Ciências 94(4), 1–19. https://doi.org/10.1590/0001-3765202220210265.

53. Razón, E.H., Sánchez, M., Naval, M.V., Gavilán, R.G., and Gómez-Serranillos, M.P. (2024). Biodiversity, traditional uses, and pharmacological potential of medicinal plants of Mozambique. Agriculture, 14, 2204. https://doi.org/10.3390/agriculture14122204

54. Rogers, C.B., and Verota, L. (1996). Chemistry and biological properties of the African Combretaceae. In: Hostettmann, K., Chinyanganya, F., Maillard, M., and Wolfender, J.-L. (editors). Chemistry, biological and pharmacological properties of African medicinal plants. University of Zimbabwe Publications, Harare, pp. 121-142

55. Schmidt, E., Lotter, M., and McCleland, W. (2017). Trees and shrubs of Mpumalanga and Kruger National Park. Jacana Media, Johannesburg.

56. Shorrocks, B., and Bates, W. (2015). The biology of African savannahs. Oxford Press, Oxford.

57. Sichone, P., Schmiedel, U., and Phiri, P. (2019). Checklist of woody plant species and their uses in the Miombo woodlands of western Zambia. World Journal of Agriculture and Soil Science, 2, 5. https://doi.org/10.33552/WJASS.2019.02.000550.

58. Sitoe, E., and Van Wyk, B.-E. (2024). An inventory and analysis of the medicinal plants of Mozambique. Journal of Ethnopharmacology, 319, 117137. https://doi.org/10.1016/j.jep.2023.117137.

59. Stace, C.A. (2002). Proposal to conserve Terminalia nom. cons. (Combretaceae) against an additional name, Bucida. Taxon, 51, 193-194. https://doi.org/10.2307/155498550

60. Stace, C.A. (2007). Combretaceae. In: Kubitzki, K. (editor). The families and genera of vascular plants volume 9. Springer, Berlin, pp. 67-82. https://doi.org/10.1007/978 3-540-32219-1_11

61. Taia, W.K., Hamdy, R.S., and E-Maged, A.M.A. (2024). Morpho-palynological assessment of the genus Terminalia L. (Combretaceae) in Egypt. Acta Botanica Croatica, 83(2), 107-114. https://doi.org/10.37427/botcro-2024-016.

62. Turner, I.M. (2020). A synopsis of the native Combretaceae in the Malay Peninsula. Webbia Journal Plant Taxonomy and Geography, 75(2), 263–280. https://doi.org/10.36253/jopt-8891.

63. Van Wyk, B., and Van Wyk, P. (2013). Field guide to trees of southern Africa. Struik Nature, Cape Town.

64. Van Wyk, B.-E., and Wink, M. (2012). Medicinal plants of the world: An illustrated scientific guide to important medicinal plants and their uses. Briza Publications, Pretoria.

65. Waly, N., Moustafa, H., Hamdy, R., and Soliman, A. (2020). Anatomical studies on the genus Terminalia L. (Combretaceae) in Egypt, I: leaf structure. Egyptian Journal of Botany, 60(3), 641-657. https://doi.org/10.21608/ejbo.2020.20019.1398.

66. Zhang, X.-R., Kaunda, J.S., Zhu, H.-T., Wang, D., Yang, C.-R., and Zhang, Y.-J. (2019). The genus Terminalia (Combretaceae): An ethnopharmacological, phytochemical and pharmacological review. Natural Products and Bioprospecting, 9, 357–392. https://doi.org/10.1007/s13659-019-00222-3.