Correlation of thyroid hormones and serum electrolytes with kidney function in chronic kidney disease: a cross-sectional observational study

Susmita Sarkar; Sanjeev Kumar Singh; Manish Kumar Kain; Shivam Yadav

doi:10.51168/7t02ge98

Autori

Susmita Sarkar Post Graduate Resident, Department of Biochemistry, GRMC, Gwalior, MP, India
Sanjeev Kumar Singh Professor and Head, Department of Biochemistry, GRMC, Gwalior, MP, India
Manish Kumar Kain Demonstrator, Department of Biochemistry, GRMC, Gwalior, MP, India
Shivam Yadav Professor and Head, Department of Nephrology, GRMC, Gwalior, MP, India

DOI:

https://doi.org/10.51168/7t02ge98

Cuvinte cheie:

Chronic kidney disease, Thyroid hormones, Electrolytes, eGFR, FT3, TSH

Rezumat

Objective

To evaluate the association of thyroid hormones and serum electrolytes with kidney function in patients with chronic kidney disease.

Methods

This cross-sectional observational study was conducted over six months (June–November 2025) in the Departments of Biochemistry and Nephrology at a tertiary care hospital. A total of 250 adults with chronic kidney disease were recruited using purposive sampling. Patients with acute kidney injury, known thyroid disease, medications affecting thyroid function or electrolytes, critical illness, or pregnancy were excluded. Serum free triiodothyronine, free thyroxine, thyroid-stimulating hormone, electrolytes, creatinine, urea, and uric acid were measured using standard laboratory methods. Estimated glomerular filtration rate was calculated using the four-variable Modification of Diet in Renal Disease equation. Correlations were assessed using Pearson's or Spearman's correlation coefficient, as appropriate.

Results

The mean age was 56.4 ± 12.8 years, with 148 (59.2%) males. The mean estimated glomerular filtration rate was 28 ± 17 mL/min/1.73 m². Reduced free triiodothyronine was observed in 69% of patients, reduced free thyroxine in 25.6%, and elevated thyroid-stimulating hormone in 20%. Free triiodothyronine showed a strong positive correlation with estimated glomerular filtration rate (r = 0.62, p < 0.001), while thyroid-stimulating hormone showed a negative correlation (r = −0.41, p < 0.01). Potassium, magnesium, and phosphorus were negatively correlated, whereas calcium showed a positive correlation (p < 0.001).

Conclusion

Thyroid hormone and electrolyte abnormalities were common and associated with declining kidney function.

Recommendations

Regular monitoring of thyroid function and serum electrolytes should be considered in patients with advanced chronic kidney disease.

Biografii autori

Susmita Sarkar, Post Graduate Resident, Department of Biochemistry, GRMC, Gwalior, MP, India

is a Postgraduate Resident in the Department of Biochemistry, Gajra Raja Medical College (GRMC), Gwalior, Madhya Pradesh, India. Her academic interests include clinical biochemistry, thyroid function, renal biomarkers, and metabolic abnormalities associated with chronic kidney disease.
Sanjeev Kumar Singh, Professor and Head, Department of Biochemistry, GRMC, Gwalior, MP, India

is Professor and Head, Department of Biochemistry, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India. His academic interests include clinical biochemistry, metabolic disorders, and laboratory medicine.
Manish Kumar Kain, Demonstrator, Department of Biochemistry, GRMC, Gwalior, MP, India

is a Demonstrator in the Department of Biochemistry, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India. His academic interests include clinical biochemistry and laboratory investigations.
Shivam Yadav, Professor and Head, Department of Nephrology, GRMC, Gwalior, MP, India

is Professor and Head, Department of Nephrology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India. His clinical and academic interests include chronic kidney disease and nephrology.

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