Clinical presentation, laboratory profile and immediate outcome of   covid-19 patients in pediatric age group in a tertiary care centre- a retrospective observational study.

Autori

  • Nitish Jena Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar
  • Chandra Sekhar Patra Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.
  • Soumya Mishra Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.
  • Dillip Dash Kumar Professor, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar
  • Bibhudutta Dash Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar
  • Priyabhasini Chinmoyee Ray Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.
  • P Niharika Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

DOI:

https://doi.org/10.51168/2jm5ey77

Cuvinte cheie:

Pandemic, Complications, COVID-19, direct cost, Multisystem Inflammatory Syndrome in Children (MISC)

Rezumat

Background

SARS‑CoV‑2 infection presentation in children is usually milder than in adults but can be severe and fatal as well particularly in association with certain comorbidities.

Aims and objectives

To Study Demographic Profile of Children Affected by Covid 19. To Study Clinical Presentation and Laboratory Profile of Covid-19 And Immediate Outcome in Children Affected by Covid -19 

Methods

This retrospective study was undertaken at a tertiary care paediatric teaching hospital. Patients aged 1month to 14 years who were diagnosed with COVID-19 and admitted in IMS & SUM hospital India. The data on clinical characteristics, Demographics profile and outcome of children (< 14 y) with COVID-19 illness from April 2020–October 2022 were reviewed and analysed.

Results

A total of 351 COVID-19-positive children (tested by reverse transcriptase polymerase chain reaction from nasopharyngeal and oropharyngeal swab) admitted during the study period. 35% children belong to age group 1-5 yr and Male children were affected more (64%) than female (36%), The most common symptoms in this study were fever (86%), cough (82%) and myalgia (48%). Abnormal CT findings ground glass opacity seen in about 24% cases. The mortality rate of patients with SARS-CoV-2 was 2% (7/351). Majority of children admitted with COVID-19 had mild to moderate illness except few groups due to the presence of comorbidities and malnutrition.

Conclusions

Children of all age groups were susceptible to COVID-19 illness with a slight male preponderance. Amongst infected, two-third were asymptomatic or had mild symptoms that required outpatient management and home isolation. The adverse outcomes were more commonly seen in infants and children > 10 y of age with associated malnutrition and comorbidities.

Biografii autori

  • Nitish Jena, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar

    is an assistant Professor, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar

  • Chandra Sekhar Patra, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

    is an assistant Professor, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

  • Soumya Mishra, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

    is an assistant Professor, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

  • Bibhudutta Dash, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar

    is a professor, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

  • Priyabhasini Chinmoyee Ray, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

    is an associate Professor, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

  • P Niharika, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

    is a post Graduate, Department of Pediatrics, Institute of Medical Science and SUM Hospital, Bhubaneswar.

Referințe

. Dhanalakshmi K, Venkataraman A, Balasubramanian S, et al. Epidemiological and clinical profile of pediatric inflamma tory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS) in Indian children. Indian Pediatr. 2020;57:1010-4.

https://doi.org/10.1007/s13312-020-2025-1

2. Revised Guidelines on Clinical Management of COVID - 19 Gov ernment of India. Ministry of Health & Family Welfare Directo rate General of Health Services (EMR Division).

3. Banerjee S, Guha A, Das A, Nandi M, Mondal R. A Prelimi nary Report of COVID-19 in Children in India. Indian Pediatr. 2020;57:963-4.

https://doi.org/10.1007/s13312-020-2004-6

4. Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: a systematic review. Eclinical Medicine. 2020;24:100433.

https://doi.org/10.1016/j.eclinm.2020.100433

5. Wu Z, McGoogan JM. Characteristics of and important les sons from the coronavirus disease 2019 (COVID-19) out break in China: summary of a report of 72 314 cases from the chinese center for disease control and prevention. JAMA. 2020;323:1239-42.

https://doi.org/10.1001/jama.2020.2648

6. Irfan O, Li J, Tang K, et al. Risk of infection and transmission of SARS- CoV- 2 among children and adolescents in households, communities and educational settings: a systematic review and meta- analysis. J Glob Health 2021;11:05013

https://doi.org/10.7189/jogh.11.05013

7. Shen K, Yang Y, Wang T, Zhao D, Jiang Y, Jin R, et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: Experts' consensus statement. World J Pediatr 2020;16:223 31. doi: 10.1007/ s12519 020 00343 7.

8. Singh P, Attri K, Mahto D, Kumar V, Kapoor D, Seth A, et al. Clinical profile of COVID 19 illness in children-Experience from a tertiary care hospital. Indian J Pediatr 2022;89:45 51. https://doi.org/10.1007/s12098 021 03822 5.

https://doi.org/10.1007/s12098-021-03822-5

9. COVID 19 Management for 1 month 19 years old: Statement by Indian Academy of Pediatrics (April 2021) Guidelines On Clinical Management Of COVID 19. Government of India Ministry of Health and Family Welfare Directorate General of Health Services (EMR Division), p. 3 5. Available from: https://www.mohfw.gov.in/pdf/ GuidelinesonClinicalManagementofCOVID1912020.pdf.

10. Parcha V, Booker KS, Kalra R, Kuranz S, Berra L, Arora G, et al. A retrospective cohort study of 12,306 pediatric COVID 19 patients in the United States. Sci Rep 2021;11:10231. doi: 10.1038/s41598 021 89553 1.

https://doi.org/10.1038/s41598-021-89553-1

11. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet 2020;395:565 74. doi: 10.1016/S0140 6736 (20) 30251 8.

https://doi.org/10.1016/S0140-6736(20)30251-8

12. Bari A, Ch A, Bano I, Saqlain N. Is leukopenia and lymphopenia a characteristic feature of COVID 19 in children? Pak J Med Sci 2021;37:869 73. doi: 10.12669/ pjms. 37.3.3848.

https://doi.org/10.12669/pjms.37.3.3848

13. Kumar J, Meena J, Yadav A, Yadav J. Radiological findings of COVID 19 in children: A systematic review and meta analysis. J Trop Pediatr 2021;67:fmaa045. doi: 10.1093/tropej/fmaa045.

https://doi.org/10.1093/tropej/fmaa045

14. Prata-Barbosa A, Lima-Setta F, Santos G, Lanziotti V, Castro R, Carla de Souza D, et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. J Pediatr (Rio J). 2020;96(5):582-92. doi: https://doi.org/10.1016/j. jped.2020.07.002

https://doi.org/10.1016/j.jped.2020.07.002

15. Murhekar MV, Bhatnagar T, Thangaraj JWV. Prevalence of Igg Antibodies Against SARS- CoV- 2 Among the General Population and Healthcare Workers in India, June-July 2021 [Internet]. Report No.: ID 3899801. Rochester, NY: Social Science Research Network, 2021. https:// papers. ssrn. com/ abstract= 3899801

https://doi.org/10.1371/journal.pmed.1003877

16. Kichloo A, Dettloff K, Aljadah M, Albosta M, Jamal S, Singh J, et al. COVID 19 and hypercoagulability: A review. Clin Appl Thromb Hemost 2020;26:1076029620962853. doi: 10.1177/1076029620962853

https://doi.org/10.1177/1076029620962853

17. Chua G, Wong J, Lam I, Ho P, Chan W, Yau F, et al. Clinical characteristics and transmission of COVID-19 in children and youths during 3 waves of outbreaks in Hong Kong. JAMA Netw Open. 2021;4(5):e218824. doi: https://doi.org/10.1001/ jamanetworkopen.2021.8824

https://doi.org/10.1001/jamanetworkopen.2021.8824

18. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145:e20200702.

https://doi.org/10.1542/peds.2020-0702

19. Kamidani S, Rostad CA, Anderson EJ. COVID- 19 vaccine development: a pediatric perspective. Curr Opin Pediatr 2021;33:144-51

https://doi.org/10.1097/MOP.0000000000000978

20. Han MS, Choi EH, Chang SH, et al. Clinical Characteristics and Viral RNA Detection in Children with coronavirus disease 2019 in the Republic of Korea. JAMA Pediatr. 2021;175:73-80.

https://doi.org/10.1001/jamapediatrics.2020.3988

21. Sarangi B, Reddy VS, Oswal JS, et al. Epidemiological and clinical characteristics of COVID-19 in Indian children in the initial phase of the pandemic. Indian Pediatr 2020; 57(10):914-7.

https://doi.org/10.1007/s13312-020-1994-4

22. Ladhani SN, Amin- Chowdhury Z, Davies HG, et al. COVID- 19 in children: analysis of the first pandemic peak in England. Arch Dis Child 2020;105:1180-5.

https://doi.org/10.1136/archdischild-2020-320042

23. .Samprathi M, Jayashree M. Biomarkers in COVID-19: an up-to-date review. Front Pediatr. 2021;8:607647. doi: https://doi.org/10.3389/ fped.2020.607647

https://doi.org/10.3389/fped.2020.607647

24. Cui Y, Tian M, Huang D, Wang X, Huang Y, Fan L, et al. A 55-day old female infant infected with 2019 novel coronavirus disease: presenting with pneumonia, liver injury, and heart damage. J Infect Dis. 2020;221(11):1775-81. doi: https://doi.org/10.1093/infdis/ jiaa113

https://doi.org/10.1093/infdis/jiaa113

25. Viner RM, Whittaker E. Kawasaki-like disease: emerging compli cation during the COVID-19 pandemic. Lancet. 2020;395:1741-3

https://doi.org/10.1016/S0140-6736(20)31129-6

26. 2Balasubramanian S, Nagendran TM, Ramachandran B, Ramanan AV. Hyper-inflammatory syndrome in a child with covid-19 treated successfully with intravenous immunoglobulin and tocilizumab. Indian Pediatr. 2020;57:681-3.

https://doi.org/10.1007/s13312-020-1901-z

Descărcări

Publicat

2026-09-17

Număr

Secțiune

Section of Pediatrics and Child Health

Cum cităm

Jena, N., Patra, C. S., Mishra, S., Kumar, D. D., Dash, B., Ray, P. C., & Niharika, P. (2026). Clinical presentation, laboratory profile and immediate outcome of   covid-19 patients in pediatric age group in a tertiary care centre- a retrospective observational study. Student’s Journal of Health Research Africa, 7(3), 7. https://doi.org/10.51168/2jm5ey77